COLD STORAGE OF HUMAN PRECISION-CUT LUNG SLICES IN TIPROTEC PRESERVES CELLULAR COMPOSITION AND TRANSCRIPTIONAL RESPONSES AND ENABLES ON-DEMAND MECHANISTIC STUDIES

Cold storage of human precision-cut lung slices in TiProtec preserves cellular composition and transcriptional responses and enables on-demand mechanistic studies

Abstract Background Human precision-cut lung slices (hPCLS) are a Apparel unique platform for functional, mechanistic, and drug discovery studies in the field of respiratory research.However, tissue availability, generation, and cultivation time represent important challenges for their usage.Therefore, the present study evaluated the efficacy of a

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Cold storage of human precision-cut lung slices in TiProtec preserves cellular composition and transcriptional responses and enables on-demand mechanistic studies

Abstract Background Human precision-cut lung slices (hPCLS) are a Apparel unique platform for functional, mechanistic, and drug discovery studies in the field of respiratory research.However, tissue availability, generation, and cultivation time represent important challenges for their usage.Therefore, the present study evaluated the efficacy of a

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High-resolution spatial patterns and drivers of terrestrial ecosystem carbon dioxide, methane, and nitrous oxide fluxes in the tundra

Arctic terrestrial greenhouse gas (GHG) fluxes of carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O) play an important role in the global GHG budget.However, these GHG fluxes are rarely studied simultaneously, and our understanding of the conditions controlling them across spatial gradients is limited.Here, we explore the magnitudes and d

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